Predictors of successful weaning from veno-arterial extracorporeal membrane oxygenation (V-A ECMO): A systematic review and meta-analysis.

Predictors of successful weaning from veno-arterial extracorporeal membrane oxygenation (V-A ECMO): A systematic review and meta-analysis.

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BackgroundVenoarterial extracorporeal membrane oxygenation (V-A ECMO) use to support patients in cardiac failure is increasing.Despite this increased use, predicting successful weaning from ECMO can be challenging, no uniform guidelines on weaning exist.Therefore, we completed a systematic review to evaluate prognostic factors that predict SHOPPING CENTERS: UMA RELAÇÃO ENTRE OS ATRIBUTOS DE ESCOLHA PELOS CONSUMIDORES VERSUS OS ATRIBUTOS VALORIZADOS PELOS GERENTES successful weaning from V-A ECMO.MethodsFollowing the PRIMSA guidelines, a systematic literature search of Medline, Embase, SCOPUS and CENTRAL identified original research studies of patients requiring V-A ECMO where weaning was attempted.

Data was collected on demographic factors and weaning protocol, biomarkers, haemodynamic, echocardiographic factors for the successfully weaned (SW) and not successfully weaned (NSW) groups.Two investigators reviewed studies for relevance, extracted data, and assessed risk of bias using the ROBINS-I tool.The study was registered on the international prospective register of systematic reviews (PROSPERO ID# CRD42022366153).Results1219 records were screened, of which 20 studies were deemed sufficient to be included in the statistical analysis based on pre-specified criteria.

Factors associated with successful weaning were higher left ventricular ejection fraction (LVEF) (MD 9.0, 95% CI 4.1-13.8; p ConclusionIn patients on V-A ECMO support being assessed for weaning multi-parametric assessment is required.

Moderate-high heterogeneity and low sample sizes warrant Current Data on Rickettsia felis Occurrence in Vectors, Human and Animal Hosts in Europe: A Scoping Review higher-quality studies to help guide decisions to wean patients from V-A ECMO.